92637-51-9Relevant articles and documents
Chemo-enzymatic route for (R)-terbutaline hydrochloride based on microbial asymmetric reduction of a substituted α-chloroacetophenone derivative
Taketomi, Shohei,Asano, Masayoshi,Higashi, Toshinori,Shoji, Mitsuru,Sugai, Takeshi
, p. 83 - 88 (2012)
To synthesize (R)-terbutaline hydrochloride, a potent β2- adrenoceptor-stimulating agent, asymmetric reduction of a substituted α-chloroacetophenone derivative with cultured whole-cell biocatalyst of the yeast Williopsis californica JCM 3600 was developed as the key reaction. The reduction proceeded by a si-facial attack of hydride in a highly enantioselective manner. Co-factor generation was enhanced by applying glycerol as the carbon source.