92659-90-0 Usage
Description
2-[(Azidoacetyl)amino]-2-deoxy-D-glucose is an azide-labeled sugar that is widely used for studying glycoproteins through in vivo metabolic labeling and chemoselective ligation.
Uses
Used in Biochemical Research:
2-[(Azidoacetyl)amino]-2-deoxy-D-glucose is used as a metabolic labeling agent for glycoproteins, allowing researchers to track and study their structure, function, and interactions within biological systems.
Used in Drug Development:
2-[(Azidoacetyl)amino]-2-deoxy-D-glucose is used as a tool in the development of drugs targeting glycoprotein-related diseases, providing insights into the role of glycoproteins in disease mechanisms and potential therapeutic targets.
Used in Diagnostic Applications:
2-[(Azidoacetyl)amino]-2-deoxy-D-glucose is used as a diagnostic agent for detecting and characterizing glycoprotein-related disorders, offering a means to identify and monitor disease progression and treatment efficacy.
Used in Pharmaceutical Industry:
2-[(Azidoacetyl)amino]-2-deoxy-D-glucose is used as a key component in the synthesis of glycoprotein-based drugs, facilitating the development of novel therapeutic agents with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 92659-90-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,6,5 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 92659-90:
(7*9)+(6*2)+(5*6)+(4*5)+(3*9)+(2*9)+(1*0)=170
170 % 10 = 0
So 92659-90-0 is a valid CAS Registry Number.
92659-90-0Relevant articles and documents
Chemoselective ligation
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, (2008/06/13)
The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).