927203-46-1

Basic information

• Product Name: 2H-Isoindole, 2-(phenylmethyl)-5-(trifluoromethyl)-
• CAS NO: 927203-46-1
• Molecular Formula: C16H12F3N
• Molecular Weight: 275.273
• Mol File: 927203-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Isoindole, 2-(phenylmethyl)-5-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Isoindole, 2-(phenylmethyl)-5-(trifluoromethyl)-(927203-46-1)
• EPA Substance Registry System: 2H-Isoindole, 2-(phenylmethyl)-5-(trifluoromethyl)-(927203-46-1)

Safety Data

• Hazardous Substances Data: 927203-46-1(Hazardous Substances Data)

Upstream product

• 927203-45-0 2-benzyl-5-trifluoromethyl-isoindole-1,3-dione 
• 26238-14-2 5-trifluoromethylbenzofuran-1,3-dione 
• 835-58-5 4-(trifluoromethyl)phthalic acid 

Relevant articles and documents

Transnitrosation of thiols from aliphatic N-nitrosamines: S-nitrosation and indirect generation of nitric oxide

S-Nitrosothiols and heme nitrosyl species are nitric oxide (NO)-derived metabolites that provide an endogenous reservoir of NO and also play roles in protein S-nitrosation, that is, transnitrosation of thiols (or thiolates) in proteins, thereby regulating protein functions and signal transduction pathways. Intriguingly, endogenous N-nitrosamines are present in similar abundance to S-nitrosothiols, and though they are thought to play similar physiological roles to S-nitrosothiols, their transnitrosation reactivities and their contribution to biological events are little understood. Herein we report aliphatic N-nitroso derivatives of 7-azabicyclo[2.2.1]heptanes, which do not act as NO donors themselves, but can transnitrosate thiols. On the basis of the calculated activation energies of transnitrosation and the aorta smooth-muscle relaxation activities of these N-nitrosamines, we present a possible scenario of S-transnitrosation from aliphatic N-nitrosamines, leading to indirect generation of NO. Copyright