92748-09-9

Basic information

• Product Name: 2-Bromobenzenesulfonamide
• Synonyms: 2-BROMOBENZENE-1-SULFONAMIDE;2-BROMOBENZENESULFONAMIDE;2-BROMOBENZENESULPHONAMIDE;BUTTPARK 89\07-69;2-Bromobenzenesulfonamide,99%;2-BROMOBENZENZENESULFONAMIDE;2-Bromo benzene sulfonyl amide;2-Bromobenzenesulfon
• CAS NO: 92748-09-9
• Molecular Formula: C₆H₆BrNO₂S
• Molecular Weight: 236.09
• Product Categories: Benzene derivates;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 92748-09-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 191-195 °C(lit.)
• Boiling Point: 374.5°Cat760mmHg
• Flash Point: 180.3°C
• Appearance: /
• Density: 1.754g/cm³
• Vapor Pressure: 8.31E-06mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.66±0.60(Predicted)
• BRN: 3253041
• CAS DataBase Reference: 2-Bromobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromobenzenesulfonamide(92748-09-9)
• EPA Substance Registry System: 2-Bromobenzenesulfonamide(92748-09-9)

Safety Data

• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 22-36/37-37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 92748-09-9(Hazardous Substances Data)

Usage

General Description

2-Bromobenzenesulfonamide is an organic compound with the chemical formula C6H6BrNO2S. It is widely used as a sulfonamide-based building block in pharmaceutical and agrochemical industries. 2-Bromobenzenesulfonamide is known for its ability to act as a carbonic anhydrase inhibitor and has potential applications in the treatment of glaucoma and other medical conditions. 2-Bromobenzenesulfonamide is also used as a reagent in chemical synthesis and is a versatile intermediate for the production of various other organic compounds. It is important to handle this chemical with care as it is known to be harmful if swallowed, inhaled, or comes into contact with skin and eyes.

InChI:InChI=1/C6H6BrNO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 6320-02-1 o-bromothiophenol 
• 5720-05-8 4-methylphenylboronic acid 
• 7732-18-5 water 
• 497-19-8 sodium carbonate 
• 615-36-1 2-bromoaniline 
• 2905-25-1 o-bromobenzenesulfonyl chloride 

Downstream Products

• 126502-30-5 N-{3-[4-(2-Bromo-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indol-5-yl}-2-cyclopentyl-acetamide 
• 126502-34-9 {3-[4-(2-Bromo-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-carbamic acid cyclopentyl ester 
• 149552-40-9 C₁₂H₉BrINO₂S 
• 92747-93-8 2-(i-butoxy-P-methylphosphinyl)-phenylsulfonamide 
• 951883-95-7 2-bromo-N-cyclohexylbenzenesulfonamide 
• 187457-54-1 2-(2-bromo-phenylsulphonyl-aminocarbonyl)-4-methyl-5-(3-tetrahydrofuryl-oxy)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 364038-80-2 2-Bromo-N-(6,7-dimethoxyquinazolin-4-yl)benzenesulphonamide 
• 113888-17-8 N--2-bromobenzenesulfonamide 
• 1027540-44-8 C₃₁H₃₈F₄N₄O₆S₂ 
• 164412-84-4 C₃₃H₄₅N₅O₆S₂ 
• 1026236-94-1 C₃₃H₃₈N₄O₅S₂ 
• 164412-68-4 N-[(2-butyl-4-(methylthio)-1-{[2'-({[(propylamino)carbonyl]amino}sulfonyl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]glycine methyl ester 

Relevant articles and documents

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan

Inspired by the well-known PPARγ partial agonism of angiotensin II type 1 receptor (AT1R) antagonists exemplified by an antihypertensive drug, Telmisartan, efforts to identify compounds with the dual activities have been pursued in order to control the two major metabolic disorders, hypertension and hyperglycemia simultaneously. Lead compound 18 derived from the AT1R antagonist, Fimasartan, has successfully presented the possibility to control the medical conditions by a single molecule.

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

A general and efficient methodology for preparing primary sulfonamides has been developed. In the presence of iodine as the catalyst and TBHP (70% in water) as the oxidant, a wide range of primary sulfonamides were prepared from the corresponding thiols and aqueous ammonia in moderate to good yields.

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.