92788-10-8 Usage
Description
(+/-) 3-ETHYL-3-(4-PYRIDINYL)-2,6-PIPERIDINEDIONE is a pharmaceutical drug belonging to the class of barbiturates. It functions as a central nervous system depressant, primarily used as a sedative and hypnotic agent for treating insomnia and other sleep disorders. (+/-) 3-ETHYL-3-(4-PYRIDINYL)-2,6-PIPERIDINEDIONE enhances the activity of the neurotransmitter GABA in the brain, resulting in a calming and sedative effect. It is available in oral form and is typically prescribed for short-term use to mitigate the risks of tolerance, dependence, and addiction. Common side effects include drowsiness, dizziness, and impaired coordination, with potential for abuse and overdose.
Used in Pharmaceutical Industry:
(+/-) 3-ETHYL-3-(4-PYRIDINYL)-2,6-PIPERIDINEDIONE is used as a sedative and hypnotic agent for the treatment of insomnia and other sleep disorders. It is utilized for its ability to enhance the activity of the neurotransmitter GABA in the brain, providing a calming and sedative effect to patients. Due to its potential for tolerance, dependence, and addiction, it is generally prescribed for short-term use.
Check Digit Verification of cas no
The CAS Registry Mumber 92788-10-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,7,8 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 92788-10:
(7*9)+(6*2)+(5*7)+(4*8)+(3*8)+(2*1)+(1*0)=168
168 % 10 = 8
So 92788-10-8 is a valid CAS Registry Number.
92788-10-8Relevant articles and documents
Preparation of 2,6-dioxopiperidine derivatives
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, (2008/06/13)
3-Alkyl- or fluoroalkyl-3-(4-pyridyl)piperidine-2,6-diones, useful in the treatment of breast cancer, of formula STR1 wherein R represents an alkyl group having 2 to 10 carbon atoms or a fluoroalkyl group having 2 to 5 carbon atoms and A is hydrogen or an alkyl group having 1 to 4 carbon atoms, are prepared by reacting a 4-pyridylacetate with an alkyl or fluoroalkyl iodide, chloride or bromide, in the presence of a sterically bulky base and reacting the product with acrylamide in the presence of a sodium or potassium branched chain alkoxide. Preferably potassium t-butoxide is used in both stages and they are carried out sequentially at room temperature in an alcoholic or polar, aprotic solvent in a single reaction vessel.
A CONCISE SYNTHESIS OF RACEMIC PYRIDOGLUTETHIMIDE AND ITS RESOLUTION USING CHIRAL STATIONARY PHASE HPLC
Boss, Aileen M.,Clissold, Derek W.,Mann, John,Markson, Andrew J.,Thickitt, Christopher P.
, p. 6011 - 6017 (2007/10/02)
We describe a 'one-pot' synthesis of the aromatase inhibitor pyridoglutethimide and its 3-octyl-analogue, together with details of the resolution of the former using chiral stationary phase hplc.
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: Derivatives with variable 1-alkyl and 3-alkyl substituents
Leung,Rowlands,Jarman,Foster,Griggs,Wilman
, p. 1550 - 1554 (2007/10/02)
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