928776-73-2Relevant articles and documents
Mono- and dihydroxylated metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity
Nakamura, Takanori,Noguchi, Tomomi,Kobayashi, Hisayoshi,Miyachi, Hiroyuki,Hashimoto, Yuichi
, p. 1709 - 1714 (2007/10/03)
Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide.