929106-57-0

Basic information

• Product Name: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, (1S,3S,5S)-, 4-methylbenzenesulfonate (1:1)
• CAS NO: 929106-57-0
• Molecular Formula: C7H8O3S.C6H8N2
• Molecular Weight: 280.348
• Mol File: 929106-57-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, (1S,3S,5S)-, 4-methylbenzenesulfonate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, (1S,3S,5S)-, 4-methylbenzenesulfonate (1:1)(929106-57-0)
• EPA Substance Registry System: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, (1S,3S,5S)-, 4-methylbenzenesulfonate (1:1)(929106-57-0)

Safety Data

• Hazardous Substances Data: 929106-57-0(Hazardous Substances Data)

Upstream product

• 361440-67-7 [1S-(1α,3β,5α)]-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid 1,1-dimethylethyl ester 
• 361442-57-1 (1S,3S,5S)-tert-butyl-3-cyano-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 709031-43-6 3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester 
• 709031-78-7 Saxagliptin hydrochloride 
• 1564265-93-5 saxagliptin 

Relevant articles and documents

Preparation method of medication saxagliptin for treating diabetes

The invention provides a preparation method of saxagliptin with a shorter synthetic route. (S)-3-amino-3-cyano-propionic ether protected by diethyl acetylenedicarboxylate and an amino group is used asa starting material in the presence of an organic phosphine ligand and a palladium catalyst, and is subjected to cyclization, decarboxylation and cyclopropanation to obtain an intermediate product (1S, 3S, 5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile p-toluenesulfonate, and then the intermediate product is reacted with carboxyl-activated (S)-N-t-butyloxycarboryl-(3-hydroxyadamantane-1-yl)glycineto increase the reaction rate and obtain a saxagliptin product with a high yield and high purity, the reaction route is greatly shortened, the yield in each step is high, the reaction time is short, the production cost is reduced, and industrial production is facilitated.

Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors

The present invention relates to novel 3-azabicyclo[3.1.0]hexane derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compou