929345-60-8

Basic information

• Product Name: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid
• Synonyms: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid
• CAS NO: 929345-60-8
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23588
• Mol File: 929345-60-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.375
• CAS DataBase Reference: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(929345-60-8)
• EPA Substance Registry System: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(929345-60-8)

Safety Data

• Hazardous Substances Data: 929345-60-8(Hazardous Substances Data)

Usage

General Description

2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid, also known as JB253, is a novel small molecule chemical compound. It belongs to the class of heterocyclic compounds and contains a pyridoindole core structure. JB253 has been investigated for its potential therapeutic applications in the treatment of neurological disorders and cognitive impairments. It has shown promising results in preclinical studies for its ability to modulate serotonin receptors and improve cognitive function. Additionally, JB253 has also been studied for its potential use in the treatment of addiction and substance abuse disorders. Its unique chemical structure and pharmacological properties make it a subject of ongoing research in the field of medicinal chemistry and drug development.

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 24589-77-3 4-hydrazinobenzoic acid hydrochloride 
• 73390-11-1 4-piperidinone monohydrate 
• 619-67-0 4-Hydrazinobenzoic acid 

Downstream Products

• 1015082-04-8 methyl 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate 
• 910797-04-5 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 1361408-14-1 C₂₈H₃₃N₃O 
• 910798-30-0 tert-butyl 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910801-35-3 C₂₄H₂₇N₃O₃S 
• 910798-31-1 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 300715-96-2 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 

Relevant articles and documents

Targeting low-druggability bromodomains: Fragment based screening and inhibitor design against the BAZ2B bromodomain

Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful tar

TETRAHYDRO-LH-PYRIDO [3,4 -B] INDOLE DERIVATIVES AS CBL RECEPTOR LIGANDS

The present invention provides tetrahydro-lH-pyrido [3, 4- b] indole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds act as cannabinoid receptor ligands (CB1) and thus may be used in the treatment of pain, cancer, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, anxiety disorders, gastrointestinal disorders and/or cardiovascular disorders.