92963-03-6Relevant articles and documents
Exploration of an imide capture/N,N-acyl shift sequence for asparagine native peptide bond formation
Mhidia, Reda,Boll, Emmanuelle,Fécourt, Fabien,Ermolenko, Mikhail,Ollivier, Nathalie,Sasaki, Kaname,Crich, David,Delpech, Bernard,Melnyk, Oleg
supporting information, p. 3479 - 3485 (2013/07/05)
Imide capture of a C-terminal peptidylazide with a side-chain thioacid derivative of an N-terminally protected aspartyl peptide leads to the formation of an imide bond bringing the two peptide ends into close proximity. Unmasking of the Nα protecting group and intramolecular acyl migration results in the formation of a native peptide bond to asparagine.