93008-63-0

Basic information

• Product Name: Carbamic acid, (4-ethylphenyl)-, phenylmethyl ester
• CAS NO: 93008-63-0
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 93008-63-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-ethylphenyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-ethylphenyl)-, phenylmethyl ester(93008-63-0)
• EPA Substance Registry System: Carbamic acid, (4-ethylphenyl)-, phenylmethyl ester(93008-63-0)

Safety Data

• Hazardous Substances Data: 93008-63-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 589-16-2 4-aminoethylbenzene 
• 371153-68-3 4-benzyloxycarbonylaminophenylacetylene 
• 1520-21-4 4-vinyl benzylamine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 227778-64-5 N-benzyloxycarbonyl-4-vinylaniline 

Relevant articles and documents

Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation

Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.

Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

A method for the flow hydrogenation of olefins and nitrobenzenes in a continuous-flow reactor containing platinum nanoparticles dispersed on an amphiphilic polystyrene-poly(ethylene glycol) resin (ARP-Pt) was developed. The hydrogenation of olefins and nitrobenzenes was completed within 31 seconds in the continuous-flow system containing ARP-Pt, giving the corresponding hydrogenated products in up to 99% yield with good chemoselectivity. Moreover, long-term (63-70 h) continuous-flow hydrogenation of styrene and nitrobenzene produced more than ten grams of ethylbenzene and aniline, respectively, without significant loss of catalytic activity. The flow hydrogenation system provides an efficient and practical method for the chemoselective reduction of olefins and nitrobenzenes. This journal is

Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Four types of heterogeneous Pd catalysts (10% Pd/C, 10% Pd/HP20, 0.5% Pd/MS3A, and 0.3% Pd/BN) were applied to the flow hydrogenation to systematically evaluate the appropriate conditions for the reduction of a wide variety of reducible functionalities. The use of 10% Pd/C and 10% Pd/HP20 allowed the hydrogenation of various reducible functionalities by a single-pass of the substrate-MeOH solution through the catalyst cartridge, while 0.5% Pd/MS3A and 0.3% Pd/BN catalyzed a novel chemoselective hydrogenation; only alkene, alkyne, azide, and nitro functionalities could be reduced with other coexisting reducible functionalities intact.