93013-37-7Relevant articles and documents
Synthesis and Quantitative Structure-Activity Relationships of Dequalinium Analogues as K+ Channel Blockers: Investigation into the Role of the Substituent at Position 4 of the Quinoline Ring
Galanakis, Dimitrios,Calder, Julie A. D.,Ganellin, C. Robin,Owen, Clive S.,Dunn, Philip M.
, p. 3536 - 3546 (1995)
Dequalinium (4) is a potent and selective blocker of small conductance Ca2+-activated K+ channels, an important but relatively little studied class.The 4-NH2 group of dequalinium has been shown to contribute significantly to blocking
Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition
Abou-Shehada, Sarah,Teasdale, Matthew C.,Bull, Steven D.,Wade, Charles E.,Williams, Jonathan M. J.
, p. 1083 - 1087 (2015/03/30)
A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.