93041-45-3

Basic information

• Product Name: 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID
• Synonyms: BUTTPARK 99\12-51;3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID;3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid;3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid 97%;3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylicacid97%
• CAS NO: 93041-45-3
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22
• Mol File: 93041-45-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 191-194
• Boiling Point: 399.1°Cat760mmHg
• Flash Point: 195.2°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 4.37E-07mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID(93041-45-3)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID(93041-45-3)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• HazardClass: IRRITANT
• Hazardous Substances Data: 93041-45-3(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxyphenyl)-5-methyl-4-isoxazolecarboxylic acid is a chemical compound with the molecular formula C12H11NO4. It is a derivative of isoxazole and is often used as a building block in the synthesis of various pharmaceuticals and other organic compounds. 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID is a white to off-white crystalline powder that is sparingly soluble in water, but more soluble in organic solvents. 3-(4-Methoxyphenyl)-5-methyl-4-isoxazolecarboxylic acid is also known for its potential uses as an anti-inflammatory and anti-bacterial agent, and is the subject of ongoing research for its potential medicinal applications.

InChI:InChI=1/C12H11NO4/c1-7-10(12(14)15)11(13-17-7)8-3-5-9(16-2)6-4-8/h3-6H,1-2H3,(H,14,15)

Upstream product

• 92029-68-0 methyl 3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxylate 
• 495417-31-7 ethyl 3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxylate 
• 31709-47-4 3-(4-methoxyphenyl)isoxazol-5(4H)-one 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 92961-55-2 4-(1-ethoxy-ethylidene)-3-(4-methoxy-phenyl)-4H-isoxazol-5-one 

Downstream Products

• 92286-62-9 3-(4-hydroxy-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 917388-78-4 tert-butyl N-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate 
• 92545-94-3 3-(4-hydroxy-phenyl)-5-methyl-isoxazole-4-carbonyl chloride 

Relevant articles and documents

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists

This Letter describes the synthesis and evaluation of mGluR7 antagonists in the isoxazolopyridone series. In the course of modification in this class, novel solid support synthesis of the isoxazolopyridone scaffold was developed. Subsequent chemical modification led to the identification of several potent derivatives with improved physicochemical properties compared to a hit compound 1. Among these, 2 showed good oral bioavailability and brain penetrability, suggesting that 2 may be useful for in vivo study to elucidate the role of mGluR7.