93041-76-0

Basic information

• Product Name: diethyl [4-(aminomethyl)benzyl]phosphonate
• CAS NO: 93041-76-0
• Molecular Formula: C₁₂H₂₀NO₃P
• Molecular Weight: 257.2659
• Mol File: 93041-76-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 386.4°C at 760 mmHg
• Flash Point: 187.5°C
• Density: 1.125g/cm³
• Vapor Pressure: 3.56E-06mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: diethyl [4-(aminomethyl)benzyl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl [4-(aminomethyl)benzyl]phosphonate(93041-76-0)
• EPA Substance Registry System: diethyl [4-(aminomethyl)benzyl]phosphonate(93041-76-0)

Safety Data

• Hazardous Substances Data: 93041-76-0(Hazardous Substances Data)

Upstream product

• 1552-41-6 diethyl [(4-cyanophenyl)methyl]phosphonate 
• 17201-43-3 4-cyanobenzyl bromide 
• 174678-80-9 diethyl [(4-α-bromomethyl)phenyldifluoromethyl]-phosphonate 
• 108228-81-5 4-(diethoxyphosphorylmethyl)-1-bromomethyl-phenyl 

Downstream Products

• 1234367-44-2 diethyl 4-((4-(benzyloxy)phenylsulfonamido)methyl)benzylphosphonate 

Relevant articles and documents

Non-peptide ITAM mimics as ZAP-70 antagonists

Non-peptide bidentate ITAM mimics as ZAP-70 antagonists have been prepared by accommodating non-hydrolyzable phosphotyrosine analogues at each end of a non-peptide spacer with a maximal P-P distance of 39 A. The most potent antagonist 5 had an IC50=0.25μM against ZAP-70 with good cellular activity. Monodentates were ca.10-fold weaker antagonists with improved cell permeability.