931-03-3 Usage
Description
Pyrrole-3-carboxylic acid, also known as 1H-pyrrole-3-carboxylic acid, is a heterocyclic organic compound characterized by a pyrrole ring with a carboxy group attached at the 3rd position. It is a white to light yellow crystalline powder that has been isolated from Penicillium chrysogenum, a species of fungus known for its production of penicillin.
Uses
Used in Pharmaceutical Industry:
Pyrrole-3-carboxylic acid is used as a key intermediate in the synthesis of isoindolinone compounds, which serve as cereblon inhibitors and GSPT1 degraders. These compounds have potential applications in the development of novel therapeutic agents for the treatment of various diseases, including cancer and other disorders.
In the preparation of isoindolinone compounds, pyrrole-3-carboxylic acid plays a crucial role in the formation of the core structure, which is responsible for the biological activity of the final product. The versatility of pyrrole-3-carboxylic acid allows for the design and synthesis of a wide range of isoindolinone derivatives with diverse pharmacological properties, making it a valuable building block in medicinal chemistry.
Furthermore, the unique chemical properties of pyrrole-3-carboxylic acid, such as its ability to form stable complexes with metal ions and its potential to act as a chelating agent, may also contribute to its utility in various other applications, including the development of new materials and catalysts. However, more research is needed to fully explore and understand the potential uses of pyrrole-3-carboxylic acid beyond its current applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 931-03-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,3 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 931-03:
(5*9)+(4*3)+(3*1)+(2*0)+(1*3)=63
63 % 10 = 3
So 931-03-3 is a valid CAS Registry Number.
931-03-3Relevant articles and documents
Carboxylation of indoles and pyrroles with CO2 in the presence of dialkylaluminum halides
Nemoto, Koji,Onozawa, Satoru,Egusa, Naoki,Morohashi, Naoya,Hattori, Tetsutaro
experimental part, p. 4512 - 4514 (2009/11/30)
The Lewis acid-mediated carboxylation of arenes with CO2 has been successfully applied to 1-substituted indoles and pyrroles by using dialkylaluminum chlorides instead of aluminum trihalides. Thus, the carboxylation of 1-methylindoles, 1-benzyl-, and 1-phenylpyrroles proceeds regioselectively with the aid of an equimolar amount of Me2AlCl under CO2 pressure (3.0 MPa) at room temperature to afford the corresponding indole-3-carboxylic acids and pyrrole-2-carboxylic acids in 61-85% yields, while the same treatment of 1,2,5-trimethylpyrrole affords the 3-carboxylic acid in 52% yield.
