931-78-2Relevant articles and documents
Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system
Liang, Shengzong,Hammond, Gerald B.,Xu, Bo
supporting information, p. 680 - 684 (2018/02/14)
A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.
Synthesizing method of pesticide intermediate 1-methylcyclohexanecarboxylic acid
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Paragraph 0019; 0020, (2017/06/02)
The invention discloses a synthesizing method of a pesticide intermediate 1-methylcyclohexanecarboxylic acid. The 1-methylcyclohexanecarboxylic acid is prepared by taking 2-methylcyclohexanol, formic acid and an R-Cl halogenating reagent as the raw materials through halogenation and substitution reactions by means of a one-pot method. The synthesizing method is novel, the defects in a traditional production process can be overcome, emission of waste acid water is reduced, the production capacity is enlarged, and the synthesizing method is green and environmentally friendly.
Kinetics and mechanism of unimolecular heterolysis of cage-like compounds: XIX. Effect of the nucleofuge nature on the activation parameters of heterolysis of 1-halo-1-methylcyclohexanes in cyclohexane. Heterolysis rate ratio in aprotic and protic solvents
Dvorko,Koshchii,Ponomareva
, p. 50 - 55 (2007/10/03)
Heterolysis of 1-bromo-1-methylcyclohexane in cyclohexane (E1 reaction) involves solvation of the transition state (ΔS≠ = -81 J mol-1K-1), while heterolysis of 1-chloro-1- methylcyclohexane is characterized by desolvation of the transition state (ΔS≠ = 92 J mol-1K-1). The probability for the formation of transition state (interaction between cationoid intermediate and solvent cavity) increases in the first case due to enhanced stability of the solvated intermediate, and in the second, due to reduction in its size. The bromide/chloride heterolysis rate ratio decreases as the ionizing power of aprotic solvent decreases and that of protic solvent increases.