932028-02-9

Basic information

• Product Name: 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone
• Synonyms: 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone
• CAS NO: 932028-02-9
• Molecular Weight: 404.527
• Mol File: 932028-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone(932028-02-9)
• EPA Substance Registry System: 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone(932028-02-9)

Safety Data

• Hazardous Substances Data: 932028-02-9(Hazardous Substances Data)

Upstream product

• 456-04-2 2-Chloro-4'-fluoroacetophenone 

Downstream Products

• 385843-98-1 tert-butyl 4-(1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethyl)piperazine-1-carboxylate 
• 932028-03-0 1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanol 

Relevant articles and documents

Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor

During the investigation of antagonists for the MC4 receptor, we found that 10ab having a naphthyl group showed almost the same binding affinity for the MC4 receptor as that of the lead compound 1 with a benzoyl group. We also developed a new type of compounds, namely, bis-piperazines, and found that the bis-piperazines 10 exhibited a high affinity for the MC4 receptor. In particular, (-)-10bg exhibited the highest affinity for the MC4 receptor with an IC50 value of 8.13 nM. In this paper, we present the design, synthesis, and structure-activity relationships of the novel bis-piperazines as MC4 receptor antagonists.