932046-87-2

Basic information

• Product Name: 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ol
• Synonyms: 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ol
• CAS NO: 932046-87-2
• Molecular Weight: 286.277
• Mol File: 932046-87-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ol(932046-87-2)
• EPA Substance Registry System: 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ol(932046-87-2)

Safety Data

• Hazardous Substances Data: 932046-87-2(Hazardous Substances Data)

Upstream product

• 932046-86-1 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ylamine 

Downstream Products

• 932046-88-3 4-chloro-2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidine 
• 932047-01-3 2-methylthio-4-(2-piperidin-1-yl-ethoxy)-6-(3-trifluoromethyl-phenyl)-pyrimidine 

Relevant articles and documents

4-PHENYL-6-SUBSTITUTED-PYRIMIDINE-2-CARBONITRILE DERIVATIVES

The invention relates to 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives having Formula (I) wherein R represents 1-3 optional substituents independently selected from (C1-4)- alkyl (optionally substituted with one or more halogens), (C1-4)alkyloxy (optionally substituted with one or more halogens) and halogen; X is NR1, O or S; R1 is H or (C1-4)alkyl; Y is (C1-4)alkyl, benzyl or (C2-6)alkyl, substituted with a group selected from OH, (C1-4)alkyloxy, NR2R3, a 4-8 membered saturated heterocyclic ring comprising 1 or 2 heteroatoms selected from O, S and NR4, and a 5 or 6-membered aromatic heterocyclic group comprising 1-4 N atoms; or R1 and Y form together with the nitrogen to which they are bonded a 5-8 membered saturated heterocyclic ring, optionally comprising a further heteroatom selected from O, S, NR4 and NO; the ring being optionally substituted with NR2R3 or with 1 to 4 (C1-3)alkyl groups; R2 and R3 are independently H or (C1-4)alkyl; or R2 and R3 form together with the nitrogen to which they are bonded a 4-8 membered saturated heterocyclic ring, optionally comprising a further heteroatom selected from O, S and NR4; R4 is H, (C1-6)alkyl,(C3-6) cycloalkyl, (C3-6)cycloalkyl(C1-4)alkyl, (C1-4)alkyloxy-(C1-4)alkyl, benzyl, amido- (C1-4)alkyl, (C1-6)alkyloxycarbonyl(C1-4)alkyl or carboxy(C1-4)alkyl; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives for the preparation of a medicament for the treatment of cathepsin K and cathepsin S related disorders, e.g. osteoporosis, atherosclerosis, inflammation and immune disorders such as rheumatoid arthritis and chronic pain.