93214-88-1

Basic information

• Product Name: 1H-Purine-2,6-dione, 8-[1,1'-biphenyl]-4-yl-3,7-dihydro-1,3-dimethyl-
• CAS NO: 93214-88-1
• Molecular Formula: C19H16N4O2
• Molecular Weight: 332.362
• Mol File: 93214-88-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Purine-2,6-dione, 8-[1,1'-biphenyl]-4-yl-3,7-dihydro-1,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purine-2,6-dione, 8-[1,1'-biphenyl]-4-yl-3,7-dihydro-1,3-dimethyl-(93214-88-1)
• EPA Substance Registry System: 1H-Purine-2,6-dione, 8-[1,1'-biphenyl]-4-yl-3,7-dihydro-1,3-dimethyl-(93214-88-1)

Safety Data

• Hazardous Substances Data: 93214-88-1(Hazardous Substances Data)

Upstream product

• 147623-03-8 8-Biphenyl-4-yl-1,3-dimethyl-6-phenyl-1,9-dihydro-pyrimido[4,5-b][1,4]diazepine-2,4-dione 
• 147622-94-4 5-Amino-6-((E)-1-biphenyl-4-yl-3-oxo-3-phenyl-propenylamino)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 85-18-7 8-chlorotheophylline 
• 5122-94-1 4-biphenylboronic acid 
• 10381-75-6 8-bromotheophylline 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 3218-36-8 4-Phenylbenzaldehyde 

Relevant articles and documents

Synthesis of 8-substituted xanthine derivatives by Suzuki cross-coupling reaction

A Suzuki cross-coupling reaction procedure was developed to prepare 8-substituted 3,7-dihydropurine-2,6-dione (xanthine) derivatives. 8-Halogen-substituted xanthines were reacted with phenyl- and styrylboronic acids. The best results were obtained using tetrakis(triphenylphosphine)palladium(0) and tripotassium phosphate in dimethylformamide. The developed procedure allows for a convergent synthesis of pharmacologically active 8-substituted xanthine derivatives.

REACTIONS OF 5,6-DIAMINO-1,3-DIMETYLURACIL WITH HALOGEN DERIVATIVES OF CHALCONES

The reaction of 5,6-diamino-1,3-dimethyluracil with 1,3-diaryl-2,3-dibromopropan-1-ones gave β-(5-amino-6-imino-1,3-dimethyluracil)chalcones, and conditions for their cyclocondensation to pyrimidinodiazepines were found.For substantiation of the reaction mechanism, the reaction of the diamine with other halogen derivatives of chalcones was studied.The IR, UV, and mass spectra of the synthesized compounds and their condensation products are discussed.