93265-81-7 Usage
Description
5-Iodo-2-pyrimidinone-2'-deoxyribose, also known as Ropidoxuridine, is a pyrimidinone nucleoside prodrug of 5-iododeoxyuridine (IUdR), an antitumor nucleoside enantiomer thymidine kinase. It is used as a potential antiviral agent and has applications in various industries.
Uses
Used in Pharmaceutical Industry:
5-Iodo-2-pyrimidinone-2'-deoxyribose is used as an antiviral agent for its potential to inhibit viral replication and reduce the severity of viral infections.
Used in Cancer Research:
5-Iodo-2-pyrimidinone-2'-deoxyribose is used as a prodrug in cancer research for its ability to be converted into the active form, 5-iododeoxyuridine (IUdR), which can be used in combination with other chemotherapeutic agents to enhance their efficacy and overcome drug resistance.
Used in Drug Development:
5-Iodo-2-pyrimidinone-2'-deoxyribose is used as a starting material in the development of new antiviral and anticancer drugs, as it can be modified and combined with other compounds to create novel therapeutic agents.
Used in Diagnostic Imaging:
5-Iodo-2-pyrimidinone-2'-deoxyribose can be used as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT), to improve the visualization of tumors and other abnormalities in the body.
Used in Biosensor Development:
5-Iodo-2-pyrimidinone-2'-deoxyribose can be used in the development of biosensors for detecting specific biomolecules or environmental contaminants, as its unique chemical properties allow for selective binding and signal transduction.
Check Digit Verification of cas no
The CAS Registry Mumber 93265-81-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,2,6 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 93265-81:
(7*9)+(6*3)+(5*2)+(4*6)+(3*5)+(2*8)+(1*1)=147
147 % 10 = 7
So 93265-81-7 is a valid CAS Registry Number.
93265-81-7Relevant articles and documents
IDOXURIDINE AND ITS ANALOGS AS NEUROPROTECTANS FOR THE TREATMENT OF PARKINSONISM
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Page/Page column 22; 27; 28, (2018/08/26)
The invention relates to compounds that are useful in the treatment of parkinsonism, such as parkinsonism in connection with Parkinson's disease (PD); dementia with Lewy bodies (DLB); multiple system atrophy (MSA); corticobasal degeneration (CBD); or progressive supranuclear palsy (PSP). The said compounds include in particular idoxuridineand analogs thereofas well as their metabolic precursors, such as ropidoxuridine.The invention further relates to method for identifying compounds useful for the treatment of parkinsonism, said methods comprising detecting the capability of compound to increase the amount of GPR37 in cell membranes.The invention further relates to methods for the chemical synthesis of ropidoxuridine.
1-(2-Deoxy-b-D-ribofuranosyl)-5-iodo-2-pyrimidinone antiviral with low host cell toxicity.
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, (2008/06/13)
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Synthesis and Biological Activities of 2-Pyrimidinone Nucleosides. 2. 5-Halo-2-pyrimidinone 2'-Deoxyribonucleosides
Efange, Simon M. N.,Alessi, Elaine M.,Shih, H. C.,Cheng, Yung-Chi,Bardos, Thomas J.
, p. 904 - 910 (2007/10/02)
1-(2-Deoxy-β-D-ribofuranosyl)-5-bromo-2-pyrimidinone (BrPdR) and 1-(2-deoxy-β-D-ribofuranosyl)-5-iodo-2-pyrimidinone (IPdR) have been synthesized by condensation of the appropriate silylated bases 2a and 2b, respectively, with 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride (8) in 1,2-dichloroethane, in the presence of SnCl4, followed by separation of the anomeric blocked nucleosides via column chromatography and subsequent deprotection with methanolic ammonia.Both BrPdR and IPdR exhibited significant antiherpes activities against various strains of HSV-1 and HSV-2, the latter compound (IPdR) showing the higher activity as well as the stronger binding to the virus-specific thimidine kinase.
