93279-10-8

Basic information

• Product Name: Z-D-Ser(N-Boc-L-Val)-OTce
• Synonyms: Z-D-Ser(N-Boc-L-Val)-OTce
• CAS NO: 93279-10-8
• Molecular Weight: 569.867
• Mol File: 93279-10-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Z-D-Ser(N-Boc-L-Val)-OTce(CAS DataBase Reference)
• NIST Chemistry Reference: Z-D-Ser(N-Boc-L-Val)-OTce(93279-10-8)
• EPA Substance Registry System: Z-D-Ser(N-Boc-L-Val)-OTce(93279-10-8)

Safety Data

• Hazardous Substances Data: 93279-10-8(Hazardous Substances Data)

Upstream product

• 78700-43-3 Z-D-Ser(Bu^t)-OTce 
• 33294-55-2 (S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic anhydride 
• 78700-33-1 Z-D-Ser-OTce 
• 13734-41-3 t-Boc-L-valine 

Downstream Products

• 713122-06-6 (Z)-D-Ser{(Z)-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH 
• 82662-00-8 N-benzyloxycarbonyl-O-(N-t-butyloxycarbonyl-L-alanyl-S-acetamidomethyl-L-cysteinyl-L-valyl)-D-serine 
• 63520-00-3 (N-benzyloxycarbonyl-D-seryl-L-alanyl-L-cysteinyl-L-valine)2(serine hydroxyl)dilactone disulfide 
• 713122-07-7 C₄₉H₆₈N₈O₁₇S₂ 
• 713122-02-2 (Z)-D-Ser[N-Boc-Cys(Acm)-L-Val]-OTce 
• 713122-04-4 (Z)-D-Ser[L-Ala-L-Cys(Acm)-L-Val]-OTce 
• 713122-03-3 (Z)-D-Ser[N-Boc-L-Ala-L-Cys(Acm)-L-Val]-OTce 
• 713122-20-4 [(1R,4S,7R,11S,14R,17S,20R,24S)-20-(9H-Fluoren-9-ylmethoxycarbonylamino)-11,24-diisopropyl-4,17-dimethyl-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28,29-dithia-2,5,12,15,18,25-hexaaza-bicyclo[12.12.4]triacont-7-yl]-carbamic acid benzyl ester 
• 713122-19-1 C₅₆H₇₂N₈O₁₇S₂ 
• 713122-05-5 (Z)-D-Ser{(Z)-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OTce 
• 713122-18-0 (Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH 
• 713122-17-9 (Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OTce 

Relevant articles and documents

Synthetic studies on quinoxaline antibiotics. III. Synthesis of nortriostin A, a triostin A analog lacking N-methyl groups on the cystine and valine residues

Nortriostin A, which is an analog of a cyclic octadepsipeptide antibiotic triostin A and contains one cystine and two valine residues substituted for the N,N'-dimethylcystine and N-methylvaline residues of the antibiotic, was synthesized with Z-D-Ser[Boc-Ala-Cys(MeBzl)-Val]-OH and Z-D-Ser[H-Ala-Cys(MeBZ)-Val]-OTce as key intermediates. The synthetic analog showed no antimicrobial activity at a concentration of 100 μg/ml and was found to exist as a single structure in solution as examined by 1H-NMR spectroscopy. The latter observation suggests that the conformer equilibrium known to occur with triostin A is a consequence of the presence of N-methyl peptide bonds in the antibiotic molecule. Nortriostin A, which is an analog of a cyclic octadepsipeptide antibiotic triostin A and contains one cystine and two valine residues substituted for the N,N prime -dimethylcystine and N-methylvaline residues of the antibiotic, was synthesized with Z-//D-Ser left bracket Boc-Ala-Cys(MeBzl)-Val right bracket -OH and Z-//D-Ser left bracket H-Ala-Cys(MeBzl)-Val right bracket -OTce as key intermediates. The synthetic analog showed no antimicrobial activity at a concentration of 100 mu g/ml and was found to exist as a single structure in solution as examined by **1H-NMR spectroscopy. The latter observation suggests that the conformer equilibrium known to occur with triostin A is a consequence of the presence of N-methyl peptide bonds in the antibiotic molecule.