93282-20-3

Basic information

• Product Name: 5-METHYLISOINDOLINE
• Synonyms: 5-METHYLISOINDOLINE;2,3-dihydro-5-methyl-1H-Isoindole;5-Methylisoindoline Hydrochloride;5-Methylisoindoline(WX604540)
• CAS NO: 93282-20-3
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 133.19
• Mol File: 93282-20-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYLISOINDOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLISOINDOLINE(93282-20-3)
• EPA Substance Registry System: 5-METHYLISOINDOLINE(93282-20-3)

Safety Data

• Hazardous Substances Data: 93282-20-3(Hazardous Substances Data)

Usage

General Description

5-Methylisoindoline is a chemical compound with the molecular formula C9H9N. It is a heterocyclic organic compound that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 5-Methylisoindoline is a stable, colorless, and odorless liquid that is soluble in most organic solvents. It is also a versatile building block for the preparation of various compounds due to its unique reactivity and structural properties. 5-Methylisoindoline has been the subject of various research studies for its potential applications in the fields of medicine and agriculture, making it an important and valuable chemical in the scientific and industrial communities.

Upstream product

• 40314-06-5 5-methyl-1H-isoindole-1,3-(2H)-dione 
• 19438-61-0 4-methylphthalic anhydride 

Relevant articles and documents

Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination

A visible-light-induced/thiourea-mediated intramolecular cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivatives. The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramolecular single electron transfer (SET) is key stage in the catalytic cycle.

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.