93290-12-1

Basic information

• Product Name: ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate
• Synonyms: ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate;Ethyl 5-ForMylpyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 5-forMyl-, ethyl ester;ethyl 5-formyl-1H-pyrazole-3-carboxylate
• CAS NO: 93290-12-1
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 170.1659
• Mol File: 93290-12-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate(93290-12-1)
• EPA Substance Registry System: ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate(93290-12-1)

Safety Data

• Hazardous Substances Data: 93290-12-1(Hazardous Substances Data)

Usage

General Description

Ethyl 3-formyl-4,5-dihydro-1H-pyrazole-5-carboxylate is a chemical compound with the molecular formula C9H12N2O3. It is commonly used as an intermediate or building block in organic synthesis and pharmaceutical research. ethyl 3-forMyl-4,5-dihydro-1H-pyrazole-5-carboxylate has potential applications in the development of drugs and other bioactive molecules due to its unique structure and reactivity. However, it is important to handle this chemical with caution and follow appropriate safety protocols due to its potential hazards. Overall, ethyl 3-formyl-4,5-dihydro-1H-pyrazole-5-carboxylate has important uses in the field of organic chemistry and pharmaceutical development.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 107-19-7 propargyl alcohol 
• 78-93-3 butanone 
• 624-67-9 Propargylic aldehyde 
• 623-47-2 propynoic acid ethyl ester 
• 840504-43-0 5-dimethoxymethyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 854699-16-4 3-formyl-1H-pyrazole-5-carboxylic acid 
• 3112-31-0 3,5-pyrazoledicarboxylic acid 

Relevant articles and documents

Stabilization and activation of unstable propynal in the zeolite nanospace and its application to addition reactions

Propynal (HC≡C-CHO), having both a C≡C triple bond and a formyl group in a molecule, is a promising building block but its labile property to easily polymerize often narrows its application for organic synthesis. In a similar way to unstable molecules, such as formaldehyde and acrolein, propynal is also stabilized and remains unchanged in supercages of Na-Y zeolite for over 30 days at ambient temperature. There, the carbonyl oxygen atoms of propynal coordinate to sodium ions in Na-Y which was proved by a 13C-DD/MAS-NMR analysis. In addition, propynal adsorbed in zeolite is sufficiently activated to allow unprecedented reactions; i.e., (1) a 1,3-dipolar cycloaddition with electron-deficient α-diazocarbonyl compounds, (2) a 1,4-addition with mono-, di-, and trimethoxy-substituted benzenes, and (3) a [2 + 2] cycloaddition of unactivated cycloalkenes. The nanospace of the zeolites keeps the products from dimerization during reaction (1) and from successive side-reactions in reaction (2). Quantum chemical calculations demonstrated that reaction (3) proceeds via a one-step-like non-concerted mechanism to afford the corresponding [2 + 2] cycloadducts. These three reactions can produce valuable synthetic intermediates retaining both a formyl group and a C=C double bond.

1,3-Dipolar cycloaddition in the synthesis of pyrazolyl-substituted nitronyl nitroxides

A new approach to the synthesis of polyfunctional pyrazolyl-substituted nitronyl nitroxides was developed based on the presynthesized pyrazole derivatives prepared by 1,3-dipolar cycloaddition. The structures of the resulting mono- and biradicals were confirmed by X-ray diffraction.

Substituted pyrazolyl compounds and methods employing such compounds

This invention pertains to novel substituted pyrazolyl compounds useful as intravenous anesthetics represented by the Formula: STR1 including geometric and optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein: one of Y and Z is nitrogen, and the other is CH; R1 is hydrogen or lower-alkyl; R2 and R3 are selected from the group consisting of hydrogen, --CHO, lower-alkylcarbonyl, lower-alkoxy carbonyl, lower-alkylaminocarbonyl, lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkenyl, lower-alkylcarbonyloxymethyl, substituted and unsubstituted heterocyclic rings, and substituted or unsubstituted aryl groups, wherein the symbol * represents a carbon atom which may be asymmetric and at least one of R2 and R3 is other than hydrogen.