93324-66-4

Basic information

• Product Name: Pyridine, 2-[1,1'-biphenyl]-4-yl-
• CAS NO: 93324-66-4
• Molecular Formula: C17H13N
• Molecular Weight: 231.297
• Mol File: 93324-66-4.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-[1,1'-biphenyl]-4-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[1,1'-biphenyl]-4-yl-(93324-66-4)
• EPA Substance Registry System: Pyridine, 2-[1,1'-biphenyl]-4-yl-(93324-66-4)

Safety Data

• Hazardous Substances Data: 93324-66-4(Hazardous Substances Data)

Upstream product

• 65007-00-3 pyridin-2-yl trifluoromethanesulfonate 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 109-04-6 2-bromo-pyridine 
• 5122-94-1 4-biphenylboronic acid 
• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 1591-31-7 4-iodo-biphenyl 
• 1365765-53-2 2-((fluoromethyl)sulfonyl)pyridine 
• 878376-35-3 pyridine-2-sulfonyl fluoride 
• 5467-74-3 4-Bromophenylboronic acid 
• 1206523-60-5 4',6''-di(pyridin-2-yl)-1,1':3',1'':3'',1'''-quaterphenyl 
• 5969-83-5 2-(4-chlorophenyl)pyridine 
• 98-80-6 phenylboronic acid 
• 110-86-1 pyridine 
• 63996-36-1 2-(4-bromophenyl]pyridine 

Downstream Products

• 1235409-61-6 4-(pyridin-2-yl)-(1,1'-biphenyl)-3-carbonitrile 
• 1259927-54-2 (2-(4-biphenyl)pyridine)acetylacetonatoplatinum(II) 
• 1430585-88-8 C₂₃H₁₈N₂O₂S 
• 1393520-20-1 N-phenyl-4-(pyridin-2-yl)biphenyl-3-carboxamide 
• 1342303-25-6 C₂₃H₂₁NO 
• 1312617-90-5 C₂₁H₁₉NO₃ 
• 1206523-60-5 4',6''-di(pyridin-2-yl)-1,1':3',1'':3'',1'''-quaterphenyl 
• 1064605-01-1 2-(2-cyclooctyl-4-phenyl-phenyl)pyridine 
• 1064605-05-5 2-(2,6-dicyclooctyl-4-phenyl-phenyl)pyridine 

Relevant articles and documents

Chelation-Assisted Copper-Mediated Direct Acetylamination of 2-Arylpyridine C-H Bonds with Cyanate Salts

In this study, the coupling of 2-phenylpyridine derivatives and potassium cyanate through C-H bond functionalization in the presence of a copper salt is developed for the first time. By this protocol, various heteroarylated acetanilide derivatives are synthesized in good yields. 2-Phenylpyridines containing electron-donating and -withdrawing groups appear to be well-tolerated by this transformation.

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation

Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.