933786-13-1Relevant articles and documents
Flipped out: Structure-guided design of selective pyrazolylpyrrole ERK inhibitors
Aronov, Alex M.,Baker, Christopher,Bemis, Guy W.,Cao, Jingrong,Chen, Guanjing,Ford, Pamella J.,Germann, Ursula A.,Green, Jeremy,Hale, Michael R.,Jacobs, Marc,Janetka, James W.,Maltais, Francois,Martinez-Botella, Gabriel,Namchuk, Mark N.,Straub, Judy,Tang, Qing,Xie, Xiaoling
, p. 1280 - 1287 (2007/10/03)
The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazoly