93413-45-7

Basic information

• Product Name: (+)-Venlafaxine hydrochloride
• Synonyms: (+)-Venlafaxine hydrochloride
• CAS NO: 93413-45-7
• Molecular Weight: 313.868
• Mol File: 93413-45-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-Venlafaxine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-Venlafaxine hydrochloride(93413-45-7)
• EPA Substance Registry System: (+)-Venlafaxine hydrochloride(93413-45-7)

Safety Data

• Hazardous Substances Data: 93413-45-7(Hazardous Substances Data)

Upstream product

• 99300-78-4 venlafaxine hydrochloride 
• 93413-69-5 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol 
• 272788-00-8 2C₁₇H₂₇NO₂*C₂₀H₁₈O₈ 
• 111-24-0 1,5-dibromo-pentane 
• 909398-05-6 methyl 3-N,N-dimethylamino-(2S)-(4-methoxyphenyl)propionate 
• 93413-46-8 (S)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol 

Relevant articles and documents

Enantioselective Synthesis of α-Aryl-β2-Amino-Esters by Cooperative Isothiourea and Br?nsted Acid Catalysis

The synthesis of α-aryl-β2-amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Br?nsted acid catalysis is demonstrated. The scope and limitatio

Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols

A process for the enantioselective synthesis of an (S)— or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described. The method involves the steps of (a) reacting an (S) or (R) 4-benzyloxazolidinone with a mixed anhydride of a methyoxyphenylacetic acid under conditions which form a oxazolidinone, (4S)— or (4R)-4-benzyl-3-[methyoxyphenyl]acetyl]-oxazolidin-2-one, (b) treating the (4S)— or (4R)-4-benzyl-3-[(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one with an aprotic amine base and titanium chloride in a chlorinated solvent under conditions which permit formation of the corresponding anion, (c) mixing the corresponding anion with titanium chloride and cylcohexanone under conditions which permit an aldol reaction to form the corresponding (4S)— or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one, (d) hydrolyzing the (4S)— or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one to form a chiral acid (2S or 2R)-(1-hydroxycyclohexyl)-methoxyphenyl)acetic acid, (e) coupling the chiral phenylacid to a secondary amine to form an amide, and (f) reducing the amide to form an (S) or (R) 1[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol or a salt thereof.