93433-65-9

Basic information

• Product Name: 2'-METHYL-3-PHENYLPROPIOPHENONE
• Synonyms: 2'-METHYL-3-PHENYLPROPIOPHENONE
• CAS NO: 93433-65-9
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.3
• Mol File: 93433-65-9.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 368.4°C at 760 mmHg
• Flash Point: 159.9°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 1.28E-05mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2'-METHYL-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYL-3-PHENYLPROPIOPHENONE(93433-65-9)
• EPA Substance Registry System: 2'-METHYL-3-PHENYLPROPIOPHENONE(93433-65-9)

Safety Data

• Hazardous Substances Data: 93433-65-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O/c1-13-7-5-6-10-15(13)16(17)12-11-14-8-3-2-4-9-14/h2-10H,11-12H2,1H3

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 501-52-0 3-Phenylpropionic acid 
• 3277-89-2 phenethylmagnesium bromide 
• 529-19-1 2-Methylbenzonitrile 
• 13565-43-0 (2E)-1-(2-methylphenyl)-3-phenyl-2-propenyl-1-one 
• 933-88-0 ortho-toluoyl chloride 
• 16419-60-6 2-Methylphenylboronic acid 
• 108-88-3 toluene 
• 645-45-4 hydrocinnamic acid chloride 
• 100-51-6 benzyl alcohol 
• 577-16-2 2-Methylacetophenone 
• 100-52-7 benzaldehyde 
• 7287-82-3 1-O-tolyl-ethanol 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 93026-54-1 β-Phenylaethyl-o-tolylcarbinylamin 
• 1436413-20-5 3-benzyl-2-(2′-methylphenyl)quinoline 
• 1588766-00-0 C₁₆H₁₅FO 
• 1588766-76-0 2-bromo-2-fluoro-3-phenyl-1-(o-tolyl)propan-1-one 
• 1588767-81-0 (S)-2-fluoro-2,3-diphenyl-1-(o-tolyl)propan-1-one 
• 83135-69-7 1-(2-methylphenyl)-3-phenyl-1-propanol 

Relevant articles and documents

Application of 4, 6-dimethyl-2-mercaptopyrimidine bivalent nickel complex in preparation of [alpha]-alkyl ketone

The invention relates to the field of metal organic chemistry, in particular to application of a 4, 6-dimethyl-2-mercaptopyrimidine bivalent nickel complex in preparation of [alpha]-alkyl ketone, which takes a 4, 6-dimethyl-2-mercaptopyrimidine nickel (II) compound as a catalyst and realizes selective preparation of [alpha]-alkyl ketone through cross-coupling reaction of secondary alcohol and primary alcohol by regulating and controlling reaction conditions. The coupling reaction is carried out in anhydrous toluene in the presence of alkali under the protection of inert gas. The application has the advantages of mild reaction system conditions and wide substrate applicability, and effectively avoids the use of organic phosphine ligands and noble metals.

Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese

A sustainable and green route to access diverse functionalized ketones via dehydrogenative–dehydrative cross-coupling of primary and secondary alcohols is demonstrated. This borrowing hydrogen approach employing a pincer N-heterocyclic carbene Mn complex displays high activity and selectivity. A variety of primary and secondary alcohols are well tolerant and result in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds via a direct outer-sphere mechanism and the dehydrogenation of the secondary alcohol substrates plays a vital role in the rate-limiting step.

Method for synthesizing alpha-alkylated ketone in water

The invention discloses a method for synthesizing alpha-alkylated ketone in water. The method comprises the following steps: adding ketone, compound alcohol, a transition metal iridium catalyst, an alkali and a solvent, namely water into a reaction container, carrying out a reflux reaction on a reaction mixture in the air for several hours, carrying out cooling to room temperature, carrying out rotary evaporation to remove the solvent, and carrying out column separation (ethyl acetate/petroleum ether) to obtain a target compound, namely alpha-alkylated ketone. A reaction equivalent substrate is used in the reaction process, so raw material waste is avoided; equivalent alkali is used, so better environmental protection performance is obtained; water reflux reaction conditions are milder; and non-toxic and harmless pure water is used as the solvent in the reaction, only water is generated as a by-product, so atom reaction economy is high, and the requirements of green chemistry are met.