93434-58-3Relevant articles and documents
Visible-Light-Driven, Metal-Free Divergent Difunctionalization of Alkenes Using Alkyl Formates
Zheng, Ming,Hou, Jing,Zhan, Le-Wu,Huang, Yan,Chen, Ling,Hua, Li-Li,Li, Yan,Tang, Wan-Ying,Li, Bin-Dong
, p. 542 - 553 (2021/01/14)
In recent decades, difunctionalization of alkenes has received considerable attention as an efficient and straightforward way to increase molecular complexity. However, examples of the difunctionalization of alkenes initiated by the intermolecular addition of alkoxycarbonyl radicals providing substituted alkanoates are still rare. Herein, we present the visible light-driven metal-free divergent difunctionalization of alkenes triggered by the intermolecular addition of alkoxycarbonyl radicals under ambient conditions. Employing alkyl formates as precursors of alkoxycarbonyl radicals and 4CzIPN as the photocatalyst, a variety of substituted alkanoates, including β-alkoxy, β-hydroxy, β-dimethoxymethoxy, and β-formyloxy alkanoates, could be facilely accessed with high functional group tolerance and high efficiency. Moreover, the mechanism study revealed that β-hydroxy alkanoates were generated by a selective decomposition of orthoformates promoted by the N-alkoxyazinium salt.
Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)
McNulty, James,Nair, Jerald J.,Vurgun, Nesrin,Difrancesco, Benjamin R.,Brown, Carla E.,Tsoi, Bernice,Crankshaw, Denis J.,Holloway, Alison C.
supporting information; experimental part, p. 718 - 722 (2012/03/11)
The discovery of a novel five-component 1,2,3-triazole-containing pharmacophore that exhibits potent and selective inhibition of aromatase (CYP 450 19A1) is described. All compounds are derived from an initial aldol reaction of a phenylacetate derivative
Kinetics and mechanism of the oxidation of alkenes by chromium(VI) in the presence of complexing agents
Meenakshisundaram, Subbiah,Gopalakrishnan,Nagarajan,Sarathi,Sumathi
, p. 73 - 79 (2007/10/03)
The catalytic activities of 2,2′-bipyridyl (bipy) and oxalic acid (Oxa) in the HCrO4- oxidation of some substituted trans-cinnamic acids have been investigated in acidic solutions. The Cr(VI)-bipy and Cr(VI)-Oxa complexes are believed to be the probable reactive electrophiles in this redox process. The kinetic data reveal that electron-releasing groups enhance the reactivity to a significant extent while the electron-withdrawing ones reduce the rate marginally. It appears that the mechanism of bipy/Oxa catalysed chromium(VI) oxidation of unsaturated systems to the corresponding cleavage products involves an electrophilic attack of the reactive complex at the C-C double bond. The formation of a ternary complex as an intermediate is envisaged to describe the redox process. In this paper, we also report on the kinetic form of the oxidation of trans-stilbene to methyl 3-hydroxy-2,3-diphenylpropanoate. The mechanistic pathway has been determined based on the kinetic behaviour and the product assignment.
