934351-23-2Relevant articles and documents
Highly selective copper-catalyzed ring expansion of vinyl thiiranes: Application to synthesis of biotin and the heterocyclic core of plavix
Rogers, Erik,Araki, Hiroshi,Batory, Lindsay A.,McInnis, Christine E.,Njardarson, Jon T.
, p. 2768 - 2769 (2007/10/03)
We report herein a new, highly selective, mild copper-catalyzed vinyl thiirane ring-expansion protocol for the formation of 2,5-dihydrothiophenes. Preliminary substrate scope and applications of this new synthetic disconnection to the formal racemic total synthesis of biotin and the synthesis of the antiplatelet blockbuster pharmaceutical agent Plavix are described. Copyright