934371-80-9

Basic information

• Product Name: C₁₂H₁₉N₂O₂P
• CAS NO: 934371-80-9
• Molecular Weight: 254.269
• Mol File: 934371-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₉N₂O₂P(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₉N₂O₂P(934371-80-9)
• EPA Substance Registry System: C₁₂H₁₉N₂O₂P(934371-80-9)

Safety Data

• Hazardous Substances Data: 934371-80-9(Hazardous Substances Data)

Upstream product

• 7328-91-8 2,2-Dimethyl-1,3-diaminopropane 
• 878-17-1 4-methylphenyl phosphorodichloridate 

Relevant articles and documents

Antitumor activities of some new 1,3,2-oxaza- and 1,3,2-diazaphosphorinanes against K562, MDA-MB-231, and HepG2 cells

New X-substituted 1,3,2-oxazaphosphorinanes, where X = NHC 6H5 (1), NHC6H4S(O) 2NH2-4 (2), NHC6 H4OCH3-4 (3), NHC6H4NO2-4 (4), OC6H 4CH3-4 (5), NHC(O)C6H4NO 2-4 (6), plus one X-substituted 1,3,2-diazaphosphorinane, where X = NHC6H4S(O)2NH2-4 (7), were synthesized and characterized by NMR, IR spectroscopy, and elemental analysis. The antitumor activities of these compounds, cyclophosphamide (CP), sulfanilamide (SA), and two X-substituted 5,5-dimethyl-1,3,2- diazaphosphorinanes, where X = NHC6H5 (8) OC 6H4CH3-4 (9), were evaluated by cell culture on K562, MDA-MB-231, and HepG2 cell lines using MTT cell proliferation assay. The IC50 values for CP and compounds 1-9 were in the range of 0.06 μM (for inhibition of HepG2 cells by compound 3) to 3.17 μM (for inhibition of HepG2 cells by compound 8). It was found that compounds 2 and 7 containing sulfonamide substituent and also SA itself are the best candidates for antitumor activity very close to CP. Springer Science+Business Media, LLC 2011.