934418-72-1Relevant articles and documents
Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0 2,6]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists
Xiao, Hai-Yun,Balog, Aaron,Attar, Ricardo M.,Fairfax, David,Fleming, Linda B.,Holst, Christian L.,Martin, Gregory S.,Rossiter, Lana M.,Chen, Jing,Cvjic, Mary-Ellen,Dell-John, Janet,Geng, Jieping,Gottardis, Marco M.,Han, Wen-Ching,Nation, Andrew,Obermeier, Mary,Rizzo, Cheryl A.,Schweizer, Liang,Spires Jr., Thomas,Shan, Weifang,Gavai, Ashvinikumar,Salvati, Mark E.,Vite, Gregory
scheme or table, p. 4491 - 4495 (2010/10/02)
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0 2,6]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several wer