934486-78-9Relevant articles and documents
Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure
Ceccarelli, Simona M.,Jaeschke, Georg,Buettelmann, Bernd,Huwyler, Joerg,Kolczewski, Sabine,Peters, Jens-Uwe,Prinssen, Eric,Porter, Richard,Spooren, Will,Vieira, Eric
, p. 1302 - 1306 (2008/09/20)
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable phar