934986-76-2Relevant articles and documents
Synthesis of enantiomerically pure cyclopentene building blocks
Tietze, Lutz F.,Stadler, Christian,B?hnke, Niels,Brasche, Gordon,Grube, Alexander
, p. 485 - 487 (2007)
An efficient synthesis of the enantiomerically pure cis-annulated cyclopentenes 2 and ent-2 was established by the use of an enzymatic transesterification and hydrolysis, respectively, followed by an S N2-type substitution with a benzyloxymethyl cuprate and a sigmatropic rearrangement. The advantage of this approach is the short sequence combined with an excellent overall yield and an enantiomeric excess of 99%. Georg Thieme Verlag Stuttgart.