93524-95-9

Basic information

• Product Name: 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI)
• Synonyms: 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI);3-(4-Pyridyl)-2-propyn-1-ol;3-(Pyridin-4-yl)prop-2-yn-1-ol
• CAS NO: 93524-95-9
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Mol File: 93524-95-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI)(93524-95-9)
• EPA Substance Registry System: 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI)(93524-95-9)

Safety Data

• Hazardous Substances Data: 93524-95-9(Hazardous Substances Data)

Usage

General Description

2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI) is a chemical compound with the molecular formula C8H7NO. It is a colorless liquid with a molecular weight of 133.15 g/mol. 2-Propyn-1-ol, 3-(4-pyridinyl)- (9CI) is primarily used in organic synthesis and as a reagent in chemical reactions. It is also known to have potential biomedical applications and may be involved in the development of pharmaceuticals. However, it is important to handle this chemical with care, as it can be toxic and harmful if absorbed through the skin or inhaled.

Upstream product

• 15854-87-2 4-iodopyridine 
• 107-19-7 propargyl alcohol 
• 19524-06-2 4-bromopyridine hydrochloride 
• 7379-35-3 4-chlorpyridine hydrochloride 

Downstream Products

• 7037-49-2 3-(piperidin-4-yl)propan-1-ol 
• 1567843-34-8 C₁₈H₂₂N₄S*ClH 
• 120690-80-4 3-(pyridin-4-yl)propionaldehyde 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 1338920-69-6 C₁₇H₁₁NO₂ 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Chemoselective Hydrogenation of Alkynes to (Z) -Alkenes Using an Air-Stable Base Metal Catalyst

A highly selective hydrogenation of alkynes using an air-stable and readily available manganese catalyst has been achieved. The reaction proceeds under mild reaction conditions and tolerates various functional groups, resulting in (Z)-alkenes and allylic alcohols in high yields. Mechanistic experiments suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperativity.

METHOD FOR PRODUCING PIPERIDINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a piperidine compound in an industrially convenient manner. SOLUTION: This invention relates to a method for producing a compound represented by general formula (I) or a salt thereof that includes the step of converting a pyridine compound having an alkynylene group in a side chain, by a contact hydrogenation reaction, into the compound represented by general formula (I) or a salt thereof (in the general formula (I), R1 is a hydrogen atom, a hydroxy group, or an optionally substituted alkyl group having carbon atoms of 1 or more and 20 or less). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT