935468-53-4Relevant articles and documents
A novel synthesis of highly substituted perhydropyrrolizines, perhydroindolizines, and pyrrolidines: Inhibition of the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1
Siegrist, Romain,Zuercher, Martina,Baumgartner, Corinne,Seiler, Paul,Diederich, Francois,Daum, Sebastian,Fischer, Gunter,Klein, Christian,Dangl, Markus,Schwaiger, Manfred
, p. 217 - 259 (2007)
In this paper, we describe the synthesis and biological evaluation of highly substituted perhydropyrrolizines that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1, an oncogenic target. The enzyme selectively catalyzes the cis/trans isomeriza