935676-08-7

Basic information

• Product Name: 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-benzoic acid methyl ester
• CAS NO: 935676-08-7
• Molecular Weight: 298.726
• Mol File: 935676-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-benzoic acid methyl ester(935676-08-7)
• EPA Substance Registry System: 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-benzoic acid methyl ester(935676-08-7)

Safety Data

• Hazardous Substances Data: 935676-08-7(Hazardous Substances Data)

Upstream product

• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 609-14-3 2-acetylpropanoic acid ethyl ester 

Relevant articles and documents

Utility of Japp-Klingemann reaction for the preparation of 5-carboxy-6-chloroindole via Fischer indole protocol

5-Carboxy-6-chloroindole, a precursor for p38 kinase inhibitor, was prepared from 4-amino-2-chloro-3-iodobenzoicacid by following the Japp-Klingemann synthetic approach. The structures of the key intermediates were also confirmed by X-ray analyses. Computational analysis was helpful in understanding the importance of the substituents at the cyclization step of the synthesis.