935861-32-8

Basic information

• Product Name: (2-(3-methoxyphenyl)pyridin-4-yl)methoxy-tert-butyldimethylsilane
• Synonyms: (2-(3-methoxyphenyl)pyridin-4-yl)methoxy-tert-butyldimethylsilane
• CAS NO: 935861-32-8
• Molecular Weight: 329.514
• Mol File: 935861-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-(3-methoxyphenyl)pyridin-4-yl)methoxy-tert-butyldimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(3-methoxyphenyl)pyridin-4-yl)methoxy-tert-butyldimethylsilane(935861-32-8)
• EPA Substance Registry System: (2-(3-methoxyphenyl)pyridin-4-yl)methoxy-tert-butyldimethylsilane(935861-32-8)

Safety Data

• Hazardous Substances Data: 935861-32-8(Hazardous Substances Data)

Upstream product

• 815584-38-4 2-bromo-4-(((tert-butyldimethylsilyl)oxy)methyl)pyridine 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 118289-16-0 (2-bromopyridin-4-yl)methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 482375-98-4 (2-(3-methoxyphenyl)pyridin-4-yl)methanol 
• 482375-99-5 4-chloromethyl-2-(3-methoxyphenyl)pyridine 

Relevant articles and documents

Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine

A series of novel N3/8-disubstituted-3,8-diazabicyclo[3.2.1]octanes in order to improve the in vitro activity of the prototype 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridyl-4-yl)methylpiperazine (1) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines. Compounds 2a,b,f and m demonstrated not only growth-inhibitory activities against leukemia cancer cells, but also fairly good activities against the growth of certain solid tumors. Among them, 2a is the most potent one with IC50 values in the low micromolar range. Moreover, compound 2a has been selected for in vitro testing on MCF-7 cell to evaluate the mode of action of this lead compound.