936000-60-1Relevant articles and documents
Synthesis of the antifungal β-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0
Leonard Jr., William R.,Belyk, Kevin M.,Conlon, David A.,Bender, Dean R.,DiMichele, Lisa M.,Liu, Ji,Hughes, David L.
, p. 2335 - 2343 (2007)
A novel three-step synthesis of the highly functionalized antifungal agent CANCIDAS (caspofungin acetate, 2) is described, starting from the natural product pneumocandin B0 (1). The highlights of the synthesis include a stereoselective formatio