936091-56-4

Basic information

• Product Name: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide
• Synonyms: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide;TG-89;BenzenesulfonaMide, N-(1,1-diMethylethyl)-3-[[5-Methyl-2-[[3-(4-MorpholinylMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]-;N-tert-butyl-3-(5-methyl-2-(3-(morpholinomethyl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide;N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethy - l)phenyl]amino]-4-pyrimidinyl]amino]benz
• CAS NO: 936091-56-4
• Molecular Formula: C26H34N6O3S
• Molecular Weight: 510.65
• Mol File: 936091-56-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 686.9±65.0 °C(Predicted)
• Appearance: /
• Density: 1.270
• PKA: 11.95±0.50(Predicted)
• CAS DataBase Reference: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide(936091-56-4)
• EPA Substance Registry System: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide(936091-56-4)

Safety Data

• Hazardous Substances Data: 936091-56-4(Hazardous Substances Data)

Usage

Description

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide is a complex organic compound with a unique chemical structure. It is characterized by its ability to inhibit the activity of JAK2, a protein tyrosine kinase enzyme that plays a crucial role in various cellular processes.

Uses

Used in Pharmaceutical Industry:
N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide is used as a JAK2 inhibitor for the treatment of various diseases and conditions. Its ability to inhibit JAK2 activity makes it a potential therapeutic agent for conditions such as rheumatoid arthritis, psoriasis, and other inflammatory disorders. By targeting JAK2, this compound can help regulate immune responses and reduce inflammation, providing relief to patients suffering from these conditions.
Additionally, due to its inhibitory effect on JAK2, this compound may also have potential applications in the treatment of certain types of cancer, as JAK2 has been implicated in the development and progression of some malignancies. Further research and clinical trials would be necessary to explore its efficacy and safety in cancer treatment.

Upstream product

• 308283-47-8 3-bromo-(N-tert-butyl)benzenesulfonamide 
• 936092-66-9 5-methyl-N₂-3-(3-(morpholinomethyl)phenyl)pyrimidine-2,4-diamine 

Relevant articles and documents

BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES

The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non receptor kinases.