936475-34-2Relevant articles and documents
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
Price, Steve,Bordogna, Walter,Braganza, Ruth,Bull, Richard J.,Dyke, Hazel J.,Gardan, Sophie,Gill, Matthew,Harris, Neil V.,Heald, Robert A.,van den Heuvel, Marco,Lockey, Peter M.,Lloyd, Julia,Molina, Aranzazu G.,Roach, Alan G.,Roussel, Fabien,Sutton, Jonathan M.,White, Anne B.
, p. 363 - 369 (2007/10/03)
Further investigation of a series of thienyl-based hydroxamic acids that included ADS100380 and ADS102550 led to the identification of the 5-pyridin-2-yl-thiophene-2-hydroxamic acid 3c, which possessed modest HDAC inhibitory activity. Substitution at the
