936500-94-6

Basic information

• Product Name: 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide
• Synonyms: 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide;PRT 060128;elinogrel;5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(MethylaMino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]aMino]carb
• CAS NO: 936500-94-6
• Molecular Formula: C20H15ClFN5O5S2
• Molecular Weight: 523.95
• Mol File: 936500-94-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.651
• CAS DataBase Reference: 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide(936500-94-6)
• EPA Substance Registry System: 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide(936500-94-6)

Safety Data

• Hazardous Substances Data: 936500-94-6(Hazardous Substances Data)

Usage

Description

Elinogrel is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 23 nM) that inhibits platelet aggregation in a human platelet-rich plasma (hPRP) assay (IC50 = 2.81 nM). It inhibits thrombosis in a mouse model of vascular injury induced by iron (III) chloride (FeCl3) when administered at a dose of 60 mg/kg.

Uses

Elinogrel is a direct acting reversible P2Y12 inhibitor, which shows an antiplatelet effect and platelet reactivity associated with cytochrome P 450 2C19 and 3A5 gene polymorphisms.

Upstream product

• 207346-42-7 2-amino-4,5-difluoro-benzoic acid,methyl ester 
• 936500-99-1 C₁₄H₉F₂N₃O₂*ClH 
• 936500-98-0 C₁₉H₁₇F₂N₃O₄ 
• 207346-43-8 C₁₅H₁₀F₂N₂O₆ 
• 849793-87-9 (5-chloro-2-thienyl)sulfonylcarbamic acid ethyl ester 
• 936501-00-7 3-(4-aminophenyl)-6-fluoro-7-(methylamino)quinazoline-2,4(1H,3H)-dione 

Relevant articles and documents

[4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO

The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and a