936553-15-0

Basic information

• Product Name: tert-Butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate
• Synonyms: tert-Butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-4-(phenylmethyl)-, 1,1-dimethylethyl ester
• CAS NO: 936553-15-0
• Molecular Formula: C₁₇H₂₆N₂O₃
• Molecular Weight: 306.39994
• Mol File: 936553-15-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate(936553-15-0)
• EPA Substance Registry System: tert-Butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate(936553-15-0)

Safety Data

• Hazardous Substances Data: 936553-15-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 57260-70-5 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1214196-85-6 1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 100-39-0 benzyl bromide 
• 1214057-04-1 4-benzyl-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 85817-34-1 4-(phenylmethyl)-2-piperazinemethanol 

Downstream Products

• 936553-16-1 7-benzylhexahydrooxazolo[3,4-a]pyrazin-3-one 
• 936553-17-2 4-benzyl-2-(methoxymethyl)-1-tert-butoxycarbonylpiperazine 
• 85817-34-1 4-(phenylmethyl)-2-piperazinemethanol 
• 1243199-03-2 4-benzyl-2-formylpiperazine-1-carboxylic acid tert-butyl ester 
• 1380336-22-0 N¹-(((R)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine 
• 1380336-23-1 N¹-(((S)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine 
• 936553-18-3 2-[4-benzyl-2-(methoxymethyl)piperazin-1-yl]-6-nitroquinoline 
• 85817-36-3 1-benzyl-3-(methoxymethyl)piperazine 
• 936553-22-9 2-[4-benzyl-2-(butoxymethyl)piperazin-1-yl]-6-nitroquinoline 
• 936553-21-8 2-[4-benzyl-2-(propoxymethyl)piperazin-1-yl]-6-nitroquinoline 
• 936553-20-7 2-[4-benzyl-2-(ethoxymethyl)piperazin-1-yl]-6-nitroquinoline 
• 936553-19-4 2-[4-benzyl-2-(hydroxymethyl)piperazin-1-yl]-6-nitroquinoline 

Relevant articles and documents

General Procedures for the Lithiation/Trapping of N-Boc Piperazines

To provide α-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic approach is required. Here, we report the development of two general and simple procedures for the racemic lithiation/trapping of N-Boc piperazin

Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds

Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA4 hydrolase (LTA4H). Most potent compounds showed good potency in both enzymatic and functional human whole blood assay. Crystallography studies further confirmed observed structure-activity relationship and LTA4H binding mode for analogs from the piperidine series.