93674-99-8

Basic information

• Product Name: RGDV
• Synonyms: RGDV;ARG-GLY-ASP-VAL;H-ARG-GLY-ASP-VAL-OH;arginyl-glycyl-aspartyl-valine
• CAS NO: 93674-99-8
• Molecular Formula: C17H31N7O7
• Molecular Weight: 445.47
• Product Categories: Peptide
• Mol File: 93674-99-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 821.1°C at 760 mmHg
• Flash Point: 450.4°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 1.12E-29mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: -15°C
• CAS DataBase Reference: RGDV(CAS DataBase Reference)
• NIST Chemistry Reference: RGDV(93674-99-8)
• EPA Substance Registry System: RGDV(93674-99-8)

Safety Data

• Hazardous Substances Data: 93674-99-8(Hazardous Substances Data)

Usage

General Description

RGDV is a synthetic peptide containing the sequence Arg-Gly-Asp-Val, which acts as a ligand for integrin receptors. It is commonly used in research and medical applications, particularly in the field of cell adhesion and migration. RGDV has been shown to promote cell attachment and spreading, as well as stimulate signaling pathways that regulate cell proliferation and differentiation. It is also utilized in the development of biomaterials for tissue engineering and drug delivery systems, due to its ability to selectively bind to specific integrin receptors on the cell surface. Overall, RGDV plays a key role in studying cell biology and has potential applications in a wide range of biomedical applications.

InChI:InChI=1/C17H31N7O7/c1-16(11(26)7-18,6-10(25)8(19)3-2-4-24-15(21)22)17(23,14(30)31)13(29)9(20)5-12(27)28/h8-9H,2-7,18-20,23H2,1H3,(H,27,28)(H,30,31)(H4,21,22,24)

Upstream product

• 90600-39-8 Boc-Arg(Nω-NO2)-Gly-OH 
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• 2188-18-3 Boc-Arg(NO₂)-OH 
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• 105916-77-6 N^α-Boc-N^δ-tosyl-Arg-OBt 
• 13836-37-8 Boc-Arg(Tos)-OH 
• 152020-30-9 Boc-Gly-Asp(OcHex)-Val-OBzl 
• 152020-31-0 (S)-2-[(S)-2-(2-Amino-acetylamino)-3-cyclohexyloxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester 
• 152020-28-5 Boc-Asp(OcHex)-Val-OBzl 
• 152020-29-6 H-Asp(OcHx)-Val-OBzl 
• 66447-55-0 ((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 21760-98-5 L-valine benzyl ester 
• 110863-06-4 Boc-Asp(OBzl)-Val-OBzl 
• 2462-34-2 L-valine benzyl ester hydrochloride 

Relevant articles and documents

RGD-peptides modifying dexamethasone: to enhance the anti-inflammatory efficacy and limit the risk of osteoporosis

Dexamethasone (Dex) is one of the most effective anti-inflammatory glucocorticoids, while the side effect, osteoporosis seriously limits its clinical use. Cell adhesion is involved in the onset of inflammation and osteoporosis, and RGD-peptides are well k

Dual-acting agents that possess free radical scavenging and antithrombotic activities: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates

A new approach to construct a single dual-acting agent is described. Compounds 6a-c are potent free radical scavengers as demonstrated by the EC50 values in PC12 cell survival assay in term of NO, H2O2, and {radical dot}OH scavenging activity. The Ach-induced vaso-relaxation assay further confirms the potent NO scavenging activity of compounds 6a-c. In addition, 6a-c are efficacious in a rat arterial thrombosis, and are active in ADP- or PAF-induced in vitro platelet aggregation assay, suggesting that compounds 6a-c also possess anti-thrombotic activities. Since both free radical and thrombogenesis are important risk factors in myocardial ischemic/reperfusion injuries, these dual-acting agents having both free radical scavenging and antithrombolic activities may potentially be beneficial toward their treatment.

Studies on Hybrid Peptides of Fragments from Fibrinogen

In the present paper the hybrid peptides of P6A and RGD, namely ARPAKRGDS 17, ARPAKRGDV19, ARPAKRGDF 21, QRPAKRGDS 18, QRPAKRGDV 20 and QRPAKRGDF 22, were synthesized via the solution method, segment condensation and TFA/TFMS A-catalyzed deprotection (in