93703-23-2

Basic information

• Product Name: 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-8-nitro-
• Synonyms: 3-methyl-8-nitroxanthine;1H-Purine-2,6-dione,3,7-dihydro-3-methyl-8-nitro
• CAS NO: 93703-23-2
• Molecular Formula: C6H5N5O4
• Molecular Weight: 211.137
• Mol File: 93703-23-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-8-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-8-nitro-(93703-23-2)
• EPA Substance Registry System: 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-8-nitro-(93703-23-2)

Safety Data

• Hazardous Substances Data: 93703-23-2(Hazardous Substances Data)

Usage

Category

Purine derivative

Related to

Xanthine (methylated and nitrated form)

Common sources

Plants and foods (e.g. coffee, tea)

Pharmaceutical research

Potential drug candidate for various medical conditions

Scientific study

Valuable tool for studying purine metabolism and its role in human health and disease

Upstream product

• 1076-22-8 3-methylxanthine 

Downstream Products

• 93703-24-3 3-methyl-8-bromoxanthine 
• 77350-93-7 3-methyl-8-chloroxanthine 

Relevant articles and documents

Purines. XIV [1]. Synthesis and properties of 8-nitroxanthine and its N- methyl derivatives

Xanthine (1) and its N-methyl derivatives 2-16 have been nitrated to the corresponding 8-nitro derivatives 17-32 under different reaction conditions. Nitration in glacial acetic acid with nitric acid works well with the N-7 unsubstituted and some of the 9-methylxanthines, respectively, whereas the 7- methylxanthine derivatives react best with nitronium tetrafluoroborate in sulfolane or glacial acetic acid. The 8-nitro group can be displaced nucleophilically to form 8-chloro-, 33, 34, 8-ethoxy-, 35, 36, and uric acid derivatives 37-40, respectively. The newly synthesized 8-nitroxanthines have been characterized by elemental analyses, pK-determinations and uv and 1H- nmr spectra.