937189-04-3

Basic information

• Product Name: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate
• Synonyms: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate
• CAS NO: 937189-04-3
• Molecular Weight: 267.306
• Mol File: 937189-04-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(937189-04-3)
• EPA Substance Registry System: [3-(p-tolyl)isoxazol-5-yl]methyl methanesulfonate(937189-04-3)

Safety Data

• Hazardous Substances Data: 937189-04-3(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 16156-58-4 prop-2-yn-1-ol methanesulfonate 
• 104-87-0 4-methyl-benzaldehyde 
• 3235-02-7 p-methylbenzaldehyde oxime 

Downstream Products

• 1240190-05-9 N-[(3-p-methylphenylisoxazol-5-yl)-methyl]-(R)-2-tert-butoxycarbonylmethylhexanamide 
• 1240190-13-9 N-[(3-p-methylphenylisoxazol-5-yl)-methyl]-(R)-2-methoxycarbonylmethylhexanamide 
• 937189-02-1 C₁₁H₁₀N₄O 
• 1240190-19-5 (R)-2-butyl-N₄-hydroxy-N₁-[(3-p-methylphenylisoxazol-5-yl)-methyl]succinamide 
• 934333-69-4 5-aminomethyl-3-p-methylphenylisoxazole 

Relevant articles and documents

Green one-pot four-component synthesis of 3,5-disubstituted isoxazoles- sulfonates and sulfonamides using a combination of NaDCC as metal-free catalyst and ultrasonic activation in water

A simple and green one-pot reaction has been proposed for the synthesis of novel 3,5-disubstituted isoxazole-sulfonates and -sulfonamides (5a-j) in water under ultrasound irradiation. The methodology is based on the use of safe and environmentally friendly reagents and allows, via in-situ 1,3-dipolar cycloaddition, an easy access to functionalized heterocycles with the creation of four new bonds (S[sbnd]O, C[sbnd]N, C[sbnd]O and C[sbnd]C). Comparison studies using classical magnetic stirring and ultrasound irradiation clearly showed that sonication promoted clean transformation, high yields (72–89%) and faster reactions (20–28 min). All the synthesized compounds were fully characterized by MS-ES, 1H NMR, 13C NMR spectroscopy and HPLC analysis.