93729-09-0

Basic information

• Product Name: N-(biphenyl-2-yl)benzenesulfonamide
• Synonyms: benzenesulfonamide, N-[1,1'-biphenyl]-2-yl-; N-(Biphenyl-2-yl)benzenesulfonamide
• CAS NO: 93729-09-0
• Molecular Formula: C₁₈H₁₅NO₂S
• Molecular Weight: 309.3822
• Mol File: 93729-09-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 488°C at 760 mmHg
• Flash Point: 248.9°C
• Density: 1.268g/cm³
• Vapor Pressure: 1.13E-09mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: N-(biphenyl-2-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(biphenyl-2-yl)benzenesulfonamide(93729-09-0)
• EPA Substance Registry System: N-(biphenyl-2-yl)benzenesulfonamide(93729-09-0)

Safety Data

• Hazardous Substances Data: 93729-09-0(Hazardous Substances Data)

Upstream product

• 145490-75-1 N-fluorobenzene sulfonamide 
• 86-00-0 2-nitrobiphenyl 
• 98-80-6 phenylboronic acid 
• 615-36-1 2-bromoaniline 
• 90-41-5 2-phenylaniline 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 1426812-97-6 5-(phenylsulfonyl)phenanthridin-6(5H)-one 
• 54682-58-5 9-(phenylsulfonyl)-9H-carbazole 
• 1330574-01-0 C₂₂H₁₉NO₄S 

Relevant articles and documents

Sequential C-S and S-N Coupling Approach to Sulfonamides

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.

Rearrangement Reaction Based on the Structure of N-Fluoro- N-alkyl Benzenesulfonamide

A novel rearrangement reaction based on the structure of N-fluoro-N-alkyl benzenesulfonamide was developed. The reaction proceeded readily at 50 °C in formic acid and generated a variety of benzenesulfonamides and aldehydes or ketones simultaneously. The reaction mechanism is believed to be a concerted mechanism that consist of 1,2-aryl migration with the departure of fluorine anion via an SN2 mechanism. This rearrangement reaction features an interesting reaction mechanism, mild reaction conditions, simple operations, and a broad substrate scope.

Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot

Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.