93790-54-6Relevant articles and documents
Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen – A new hybrid design paradigm
Palermo, Anthony F.,Diennet, Marine,El Ezzy, Mohamed,Williams, Benjamin M.,Cotnoir-White, David,Mader, Sylvie,Gleason, James L.
supporting information, p. 4428 - 4440 (2018/08/06)
Hybrid antiestrogen/histone deacetylase (HDAC) inhibitors were designed by appending zinc binding groups to the 4-hydroxystilbene core of 4-hydroxytamoxifen. The resulting hybrids were fully bifunctional, and displayed high nanomolar to low micromolar IC
Synthesis and growth inhibition activity of fluorinated derivatives of tamoxifen
Malo-Forest, Bianca,Landelle, Grégory,Roy, Jessye-Ann,Lacroix, Jacques,Gaudreault, René C.,Paquin, Jean-Fran?ois
, p. 1712 - 1715 (2013/03/29)
The design and synthesis of 11 fluorinated derivatives of tamoxifen are described. Growth inhibition values (GI50) on human HT-29, M21, MCF7, and MDA-MB-231 tumor cells are also reported. In general, the GI50 values are similar or sl
Zirconocene-mediated highly regio- and stereoselective synthesis of multisubstituted olefins starting from 1-alkynylboronates
Nishihara, Yasushi,Miyasaka, Mitsuru,Okamoto, Masanori,Takahashi, Hideki,Inoue, Eiji,Tanemura, Kenki,Takagi, Kentaro
, p. 12634 - 12635 (2008/03/13)
Multisubstituted olefins are efficiently prepared by the zirconocene-mediated regio- and stereoselective coupling between 1-alkynylboronates and ethylene, followed by sequential transformation in moderate to high yields. The proper combination of substrates and reaction conditions is important for high yields. The synthesis of various tetrasubstituted alkenes in a regio- and stereocontrolled manner is described. This methodology has been applied to the synthesis of (Z)-tamoxifen in a concise, regio- and stereoselective manner. This multicomponent coupling strategy involves the characteristics of 1-alkynylboronates toward high selectivities followed by palladium(0)-mediated cross-coupling with aryl halides. Copyright