93793-83-0Relevant articles and documents
A preparation method for rosacea acetate hydrochloride
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, (2021/12/07)
The present invention relates to the field of pharmaceutical preparation technology, in particular to a method for preparing rosatidine acetate hydrochloride. The present invention adopts m-hydroxybenzoic acid as a starting material, a wide range of sources, inexpensive, and it can be prepared by oxidation of m-hydroxytoluene, without involving a toxicity warning structure and nitrosamine impurities; at the same time, in this preparation process only involves a genotoxic warning structure substance, reducing the risk of medication of subsequent drugs.
Preparation method of roxatidine acetate hydrochloride
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, (2020/05/01)
The invention relates to a preparation method of roxatidine acetate hydrochloride. The preparation method comprises the following steps: step 1, dissolving m-cresol and 3-chloropropylamine hydrochloride into a reaction solvent according to a certain ratio, carrying out a reaction in the presence of an alkali, extracting after the reaction, and concentrating after simple purification to obtain an intermediate 1; 2, dissolving the intermediate 1 and an alkali in a reaction solvent according to a certain ratio, adding acetoxyacetyl chloride in a dropwise manner at a low temperature, and extracting and concentrating after the reaction of the intermediate 1 is finished to obtain an intermediate 2; 3, carrying out a bromination reaction on the intermediate 2 and N-bromosuccinimide, and directlycarrying out water washing extraction to obtain an intermediate 3; 4, carrying out a reaction on the intermediate 3 and excessive piperidine in a solvent, concentrating, extracting with dichloromethane, drying, and further purifying with acetic anhydride to obtain roxatidine acetate; 5, dissolving the intermediate 3 in acetone, adding hydrochloric acid in a dropwise manner to form a salt, filtering, and drying; and 6, mixing with absolute ethyl alcohol, filtering, carrying out cooling crystallization, and drying to obtain the roxatidine acetate hydrochloride.
Preparation method of roxatidine acetate hydrochloride
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, (2017/07/20)
The invention discloses a preparation method of roxatidine acetate hydrochloride. The preparation method is characterized by adopting m-hydroxybenzaldehyde and piperidine as raw materials for carrying out chemical synthesis under the conditions of microwave radiation and high frequency ultrasonic wave, so that the product yield is improved, the reaction time is shortened, the cost is reduced, the product purity is improved, the total impurities are reduced, and an ideal effect is achieved.