938163-84-9Relevant articles and documents
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: Discovery of an unusual structure-activity relationship
Rachid, Zakaria,Brahimi, Fouad,Qiu, Qiyu,Williams, Christopher,Hartley, Janet M.,Hartley, John A.,Jean-Claude, Bertrand J.
, p. 2605 - 2608 (2008/02/04)
To enhance the potency of "combi-molecules", we designed 6a-d and 18 to release an inhibitor of EGFR TK and a bifunctional alkylator. The combi-molecules blocked EGFR TK with potency increasing with the basicity of the mustard moiety. They selectively kil
