938300-53-9

Basic information

• Product Name: 4-(4-chloro-3,5-dimethylphenoxy)benzonitrile
• Synonyms: 4-(4-chloro-3,5-dimethylphenoxy)benzonitrile
• CAS NO: 938300-53-9
• Molecular Weight: 257.719
• Mol File: 938300-53-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-chloro-3,5-dimethylphenoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chloro-3,5-dimethylphenoxy)benzonitrile(938300-53-9)
• EPA Substance Registry System: 4-(4-chloro-3,5-dimethylphenoxy)benzonitrile(938300-53-9)

Safety Data

• Hazardous Substances Data: 938300-53-9(Hazardous Substances Data)

Upstream product

• 88-04-0 4-Chloro-3,5-dimethylphenol 
• 1194-02-1 4-fluorobenzonitrile 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 938239-48-6 (4-(4-chloro-3,5-dimethylphenoxy)phenyl)methanamine 

Relevant articles and documents

Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors

We report design of a series of 2,4-diamino triazines as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors. The synthesized compounds were evaluated against Mtb (H37Rv and Dormant stage H37Ra), their cytotoxicity was assessed (HepG2 and A549 cell lines), and selectivity toward Mtb was evaluated by testing against other bacterial strains. Some derivatives showed promising activity along with low cytotoxicity. The most potent compound in the whole cell assay (MIC 0.325 μM against H37Rv) showed selectivity in the enzyme assay and exhibited synergy with second line anti-TB agent p-amino salicylic acid. This study therefore provides promising molecules for further development as antituberculosis DHFR inhibitors.