939043-30-8

Basic information

• Product Name: 2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-aMine
• Synonyms: 2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-aMine
• CAS NO: 939043-30-8
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• Mol File: 939043-30-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-aMine(939043-30-8)
• EPA Substance Registry System: 2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-aMine(939043-30-8)

Safety Data

• Hazardous Substances Data: 939043-30-8(Hazardous Substances Data)

Usage

General Description

2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-amine is a chemical compound that belongs to the class of benzoazepines. It is a tricyclic compound with a benzene ring fused to a seven-membered azepine ring, and an amine group attached at the seventh position. This chemical is used as a building block in the synthesis of various pharmaceutical compounds, particularly for the development of CNS (central nervous system) drugs. It has been studied for its potential therapeutic effects in the treatment of depression, anxiety, and related psychiatric disorders. Additionally, it is also used as a research tool in the study of neuropharmacology and drug development.

Upstream product

• 648876-22-6 7-(2,5-dimethyl-pyrrol-1-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepine 
• 3470-53-9 6-amino-1-tetralone 
• 444588-42-5 7-(2,5-dimethyl-pyrrol-1-yl)-2,3,4,5-tetrahydro-benzo[c]azepin-1-one 
• 66361-68-0 (E)-6-bromo-3,4-dihydronaphthalen-1(2H)-one oxime 
• 66361-67-9 6-bromo-3,4-dihydro-2H-naphthalen-1-one 
• 1022954-85-3 6-aminotetralin-1-one oxime 
• 22246-68-0 7-amino-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one 

Downstream Products

• 939043-33-1 [(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide 
• 939043-34-2 1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate 
• 939043-32-0 1,1-Dimethylethyl 7-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate 
• 939043-31-9 tert-butyl 7-amino-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate 
• 444588-28-7 7-benzyloxycarbonylamino-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid benzyl ester 

Relevant articles and documents

HETEROARYL COMPOUNDS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. Such compounds have general formula I or a pharmaceutically acceptable salt thereof, wherein Ring A, Ring B, W, Ry, R3 and R4 are as defined herein.

BICYCLOANILINE DERIVATIVE

The invention relates to a compound of a general formula (I): wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.